Prevalence of anti-phospholipase A2 receptor antibodies in Japanese patients with membranous nephropathy

Idiopathic membranous nephropathy and anti-phospholipase A2 receptor antibodies.

Anti-Phospholipase A2 Receptor (PLA2R) Antibody and Glomerular PLA2R Expression in Japanese Patients with Membranous Nephropathy

The phospholipase A2 receptor (PLA2R) is the major target antigen (Ag) in idiopathic membranous nephropathy (IMN). Recently, several types of immunoassay systems for anti-PLA2R antibody (Ab) have been developed. However, the correlation of serum anti-PLA2R Abs and glomerular expression of PLA2R Ag, and their association with clinicopathological characteristics have yet to be proven in Japanese ...

Phospholipase A2 receptor antibodies in membranous nephropathy: unresolved issues.

The discovery of theM-type phospholipase A2 receptor (PLA2R) as a major antigen in idiopathic membranous nephropathy (iMN) was a breakthrough and established iMN as an autoimmune disease.1 Subsequent studies confirmed that antibodies against PLA2R were present in approximately 70% of incident iMN patients (reviewed by Hofstra and Wetzels2). The potential role ofmeasuring PLA2R antibodies for cl...

Anti-phospholipase A2 receptor antibody in membranous nephropathy.

The M-type phospholipase A2 receptor (PLA2R) is a target autoantigen in adult idiopathic membranous nephropathy (MN), but the prevalence of autoantibodies against PLA2R is unknown among Chinese patients with MN. Here, we measured anti-PLA2R antibody in the serum of 60 patients with idiopathic MN, 20 with lupus-associated MN, 16 with hepatitis B (HBV)-associated MN, and 10 with tumor-associated ...

Anti-Phospholipase A2 Receptor Antibodies in Membranous Nephropathy: from Bench to the Patient

Membranous nephropathy (MN) is a glomerular disease histologically characterized by an uniform thickening of glomerular basement membranes (GBM) caused by subepithelial electrondense deposits of immune complexes, in which the antibody is an IgG. In about 2/3 of cases the etiology of MN is unknown and the disease is called primary or idiopathic. In the remaining cases MN may be secondary to syst...